ILS-920 [892494-07-4]
T13734
CAS Number892494-07-4
Product group Chemicals
Molecular Weight1023.3
Overview
- SupplierTargetMol Chemicals
- Product NameILS-920 [892494-07-4]
- Delivery Days Customer999
- CAS Number892494-07-4
- CertificationResearch Use Only
- Chemical NameILS-920
- Molecular FormulaC57H86N2O14
- Molecular Weight1023.3
- Scientific DescriptionILS-920 is a Rapamycin analog characterized by diminished immunosuppressive effects but remarkable neuroprotective properties. It exhibits selective binding affinity towards the immunophilin FKBP52 as well as the beta1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 displays a notable 200-fold preference for FKBP52 over FKBP12.
- Shelf life instruction3 years
- SMILESC[C@@H]1[C@]2(N(O[C@](CC2)(/C=C(\C)/[C@@H](OC)C[C@]3(O[C@@](O)(C(=O)C(=O)N4[C@](C(=O)O[C@]([C@@H](C[C@H]5C[C@@H](OC)[C@H](O)CC5)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C1)[H])(CCCC4)[H])[C@H](C)CC3)[H])[H])C6=CC=CC=C6)[H]
- Storage Instruction-20°C
- UNSPSC12352200
References
- Ruan B, Pong K, Jow F, et al. Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008,105(1):33-8.Read this paper
MSDS
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