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ProductsBack/ILS-920 [892494-07-4]
ILS-920 [892494-07-4]

ILS-920 [892494-07-4]

Research Use Only
T13734
TargetMol Chemicals
CAS Number892494-07-4
DownloadMSDS
Product group Chemicals
Molecular Weight1023.3
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    ILS-920 [892494-07-4]
  • Delivery Days Customer
    16
  • CAS Number
    892494-07-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    ILS-920
  • Molecular Formula
    C57H86N2O14
  • Molecular Weight
    1023.3
  • Scientific Description
    ILS-920 is a Rapamycin analog characterized by diminished immunosuppressive effects but remarkable neuroprotective properties. It exhibits selective binding affinity towards the immunophilin FKBP52 as well as the beta1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 displays a notable 200-fold preference for FKBP52 over FKBP12.
  • Shelf life instruction
    3 years
  • SMILES
    C[C@@H]1[C@]2(N(O[C@](CC2)(/C=C(\C)/[C@@H](OC)C[C@]3(O[C@@](O)(C(=O)C(=O)N4[C@](C(=O)O[C@]([C@@H](C[C@H]5C[C@@H](OC)[C@H](O)CC5)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C1)[H])(CCCC4)[H])[C@H](C)CC3)[H])[H])C6=CC=CC=C6)[H]
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Ruan B et al., 2008 Jan 8, Proc Natl Acad Sci U S A
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