IMR-1

MedChem Express

IMR-1 [310456-65-6]

10

310456-65-6

Research Use Only

98.95

C15H15NO5S2

353.41

IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC 50 of 26 microM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth [1] .

O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

-20°C,2°C to 8°C

12352200