IMR-1

AbMole BioScience

IMR-1

9

310456-65-6

Chemical

Research Use Only

C15H15NO5S2

353.41

IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 uM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity.

CCOC(=O)COC1=CC=C(C=C1OC)\C=C2/SC(=S)NC2=O

12352200