Inavolisib

MedChem Express

Inavolisib [2060571-02-8]

10

2060571-02-8

Research Use Only

99.96

C18H19F2N5O4

407.37

Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kalpha inhibitor ( IC 50 =0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kalpha. Inavolisib can be used for the study of breast cancer [1] .

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

-20°C,2°C to 8°C

12352200