Inavolisib (GDC-0077)

AbMole BioScience

Inavolisib (GDC-0077)

9

2060571-02-8

Chemical

Research Use Only

C18H19F2N5O4

407.37

Inavolisib (GDC-0077; RG6114) is a potential best-in-class, orally selective PI3Kalfa inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutants compared to wild-type PI3Kalfa. It can trigger the degradation of mutation-producing PIK3alfa.

CC(NC1=CC=C2C(=C1)OCC[N]3C=C(N=C23)N4C(COC4=O)C(F)F)C(N)=O

12352200