ING3 antibody [N2N3]
GTX102480
Overview
- SupplierGeneTex
- Product NameING3 antibody [N2N3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID54556
- Target nameING3
- Target descriptioninhibitor of growth family member 3
- Target synonymsEaf4; ING2; inhibitor of growth protein 3; MEAF4; p47ING3
- HostRabbit
- IsotypeIgG
- Protein IDQ9NXR8
- Protein NameInhibitor of growth protein 3
- Scientific DescriptionThe protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Overexpression of ING3 is associated with attenuation of migration and invasion in breast cancer. Li H et al., 2021 Jul, Exp Ther MedRead more