WB analysis of human fetal brain tissue using GTX47437 INSIG1 antibody at 0.2-1microg/ml.
WB analysis of human fetal brain tissue using GTX47437 INSIG1 antibody at 0.2-1microg/ml.
INSIG1 antibody, Internal
GTX47437
Overview
- SupplierGeneTex
- Product NameINSIG1 antibody, Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 0.2-2.5 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5-1 mg/ml
- ConjugateUnconjugated
- Gene ID3638
- Target nameINSIG1
- Target descriptioninsulin induced gene 1
- Target synonymsCL6; INSIG-1 membrane protein; insulin-induced gene 1 protein
- HostRabbit
- IsotypeIgG
- Protein IDO15503
- Protein NameInsulin-induced gene 1 protein
- Scientific DescriptionThis gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203