Insulin antibody [HMV308] HistoMAX(tm)

GeneTex

Insulin antibody [HMV308] HistoMAX(tm)

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Antibody

Research Use Only

Monoclonal

HMV308

Unconjugated

INS

insulin

IDDM; IDDM1; IDDM2; ILPR; insulin; IRDN; MODY10; PNDM4; preproinsulin; proinsulin

Rabbit

IgG

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Human

2°C to 8°C,-20°C or -80°C

12352203