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InVivoMAb anti-human CD8alpha

Research Use Only
BE0004-2
Bio X Cell
ApplicationsOther Application
Product group Antibodies
ReactivityHuman
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-human CD8alpha
  • Delivery Days Customer
    7
  • Applications
    Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    OKT-8
  • Concentration
    4-11 mg/ml
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    The OKT-8 monoclonal antibody reacts with human CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The OKT-8 antibody does not block the binding of the anti-human CD8α antibodies RPA-T8 and HIT8a.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components. Chijioke O et al., 2015 Sep 1, J Infect Dis
    Read more
  • Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection. Chijioke O et al., 2013 Dec 26, Cell Rep
    Read more
  • Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. Billerbeck E et al., 2013 Aug 15, J Immunol
    Read more

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