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InVivoPlus anti-mouse CD8alpha
BP0117
Overview
- SupplierBio X Cell
- Product NameInVivoPlus anti-mouse CD8alpha
- Delivery Days Customer7
- ApplicationsWestern Blot, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDYTS 169.4
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG2b
- Scientific DescriptionThe YTS 169.4 monoclonal antibody reacts with mouse CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The YTS 169.4 antibody exhibits depleting activity when used in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
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- TGF-beta signalling is required for CD4+ T cell homeostasis but dispensable for regulatory T cell function. Sledzinska A et al., 2013 Oct, PLoS BiolRead more
- Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation. Dai M et al., 2013 May, J ImmunotherRead more