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InVivoPlus anti-mouse CD8alpha
BP0117
Overview
- SupplierBio X Cell
- Product NameInVivoPlus anti-mouse CD8alpha
- Delivery Days Customer7
- ApplicationsWestern Blot, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDYTS 169.4
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostRat
- IsotypeIgG2b
- Scientific DescriptionThe YTS 169.4 monoclonal antibody reacts with mouse CD8α. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The YTS 169.4 antibody exhibits depleting activity when used in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Triplett TA et al., 2018 Sep, Nat BiotechnolRead more
- Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression. Vashist N et al., 2018, Front ImmunolRead more
- Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells. Burrack KS et al., 2015 Oct, PLoS PathogRead more
- Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance. Li Z et al., 2015 Oct, Transpl ImmunolRead more
- Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Carmi Y et al., 2015 May 7, NatureRead more
- NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Wensveen FM et al., 2015 Apr, Nat ImmunolRead more
- Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Pastille E et al., 2014 Aug 15, Cancer ResRead more
- Central memory CD8+ T lymphocytes mediate lung allograft acceptance. Krupnick AS et al., 2014 Mar, J Clin InvestRead more
- TGF-beta signalling is required for CD4+ T cell homeostasis but dispensable for regulatory T cell function. Sledzinska A et al., 2013 Oct, PLoS BiolRead more
- Long-lasting complete regression of established mouse tumors by counteracting Th2 inflammation. Dai M et al., 2013 May, J ImmunotherRead more
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