InVivoMAb anti-mouse 4-1BB (CD137)

Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity. Qi X et al., 2019 May 20, Nat Commun

c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. Giardino Torchia ML et al., 2015 Sep, Eur J Immunol

NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Kobayashi T et al., 2015 Mar, Oncoimmunology

Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Guillerey C et al., 2015 May, J Clin Invest

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Tewalt EF et al., 2012 Dec 6, Blood

Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Verbrugge I et al., 2012 Jul 1, Cancer Res

4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. Vezys V et al., 2011 Aug 15, J Immunol