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InVivoPlus anti-mouse 4-1BB (CD137)
BP0239
Overview
- SupplierBio X Cell
- Product NameInVivoPlus anti-mouse 4-1BB (CD137)
- Delivery Days Customer7
- ApplicationsOther Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3H3
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostRat
- IsotypeIgG2a
- Scientific DescriptionThe 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF-κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The 3H3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling in vivo.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity. Qi X et al., 2019 May 20, Nat CommunRead more
- c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. Giardino Torchia ML et al., 2015 Sep, Eur J ImmunolRead more
- NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Kobayashi T et al., 2015 Mar, OncoimmunologyRead more
- Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Guillerey C et al., 2015 May, J Clin InvestRead more
- Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. Tewalt EF et al., 2012 Dec 6, BloodRead more
- Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Verbrugge I et al., 2012 Jul 1, Cancer ResRead more
- 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. Vezys V et al., 2011 Aug 15, J ImmunolRead more
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