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InVivoMAb anti-mouse CD3epsilon

Research Use Only
BE0001-1
Bio X Cell
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, Other Application
Product group Antibodies
ReactivityMouse
Price on request
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse CD3epsilon
  • Delivery Days Customer
    7
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    145-2c11
  • Concentration
    4-11 mg/ml
  • Host
    Hamster
  • Isotype
    IgG1
  • Scientific Description
    The 145-2C11 monoclonal antibody reacts with mouse CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis via binding and stimulating the TCR. Additionally, the 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3ε+ T lymphocytes.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling. Lacher SM et al., 2018 Nov, J Autoimmun
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  • Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis. Wendland K et al., 2018 Jul 15, J Immunol
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  • NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Glasner A et al., 2018 Jan 16, Immunity
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  • Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Ron-Harel N et al., 2016 Jul 12, Cell Metab
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  • Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Xu H et al., 2015 Dec, Nat Immunol
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  • PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. Awe O et al., 2015 Oct 15, J Immunol
    Read more
  • The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Liu H et al., 2015 Sep 3, Mol Cell
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  • Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. Kim YU et al., 2015, PLoS One
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  • CRK proteins selectively regulate T cell migration into inflamed tissues. Huang Y et al., 2015 Mar 2, J Clin Invest
    Read more
  • A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling. Gu AD et al., 2015 Jan 20, Immunity
    Read more

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