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InVivoMAb anti-mouse CD3epsilon
BE0001-1
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, Other Application
Product group Antibodies
ReactivityMouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse CD3epsilon
- Delivery Days Customer7
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID145-2c11
- Concentration4-11 mg/ml
- Estimated Purity>95%
- HostHamster
- IsotypeIgG1
- Scientific DescriptionThe 145-2C11 monoclonal antibody reacts with mouse CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis via binding and stimulating the TCR. Additionally, the 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3ε+ T lymphocytes.
- ReactivityMouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- NF-kappaB inducing kinase (NIK) is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling. Lacher SM et al., 2018 Nov, J AutoimmunRead more
- Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis. Wendland K et al., 2018 Jul 15, J ImmunolRead more
- NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Glasner A et al., 2018 Jan 16, ImmunityRead more
- Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Ron-Harel N et al., 2016 Jul 12, Cell MetabRead more
- Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Xu H et al., 2015 Dec, Nat ImmunolRead more
- PU.1 Expression in T Follicular Helper Cells Limits CD40L-Dependent Germinal Center B Cell Development. Awe O et al., 2015 Oct 15, J ImmunolRead more
- The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells. Liu H et al., 2015 Sep 3, Mol CellRead more
- Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. Kim YU et al., 2015, PLoS OneRead more
- CRK proteins selectively regulate T cell migration into inflamed tissues. Huang Y et al., 2015 Mar 2, J Clin InvestRead more
- A critical role for transcription factor Smad4 in T cell function that is independent of transforming growth factor beta receptor signaling. Gu AD et al., 2015 Jan 20, ImmunityRead more
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