InVivoMAb anti-mouse IL-2

Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection. Littwitz-Salomon E et al., 2015 Jul 30, Retrovirology

GITR intrinsically sustains early type 1 and late follicular helper CD4 T cell accumulation to control a chronic viral infection. Clouthier DL et al., 2015 Jan, PLoS Pathog

Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context. Baeyens A et al., 2015 Feb 1, J Immunol

Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2. McKinstry KK et al., 2014 Nov 5, Nat Commun

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells. Mizui M et al., 2014 Sep 1, J Immunol

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. Srivastava S et al., 2014 May 5, J Exp Med

IL-2-dependent adaptive control of NK cell homeostasis. Gasteiger G et al., 2013 Jun 3, J Exp Med

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. Gratz IK et al., 2013 May 1, J Immunol

Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes. Smith C et al., 2011 May 15, J Immunol

IL-2 complex treatment can protect naive mice from bacterial and viral infection. Hamilton SE et al., 2010 Dec 1, J Immunol