InVivoMAb anti-mouse TIM-1 (CD365)

Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. Lee HH et al., 2010 Nov 1, J Immunol

Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. Mariat C et al., 2009 Feb 1, J Immunol

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. Degauque N et al., 2008 Feb, J Clin Invest

Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. Xiao S et al., 2007 Jul 9, J Exp Med

TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Umetsu SE et al., 2005 May, Nat Immunol