InVivoMAb anti-mouse TIM-3 (CD366)

Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer. Liu JF et al., 2018 Mar 5, J Exp Clin Cancer Res

TIGIT predominantly regulates the immune response via regulatory T cells. Kurtulus S et al., 2015 Nov 2, J Clin Invest

A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1. Ngiow SF et al., 2015 Sep 15, Cancer Res

Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells. Tripathi S et al., 2015, PLoS One

Programmed death-1 impairs secondary effector lung CD8+ T cells during respiratory virus reinfection. Erickson JJ et al., 2014 Nov 15, J Immunol

Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Mittal D et al., 2014 Jul 15, Cancer Res

Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Dolina JS et al., 2014 Apr, Hepatology

Combining regulatory T cell depletion and inhibitory receptor blockade improves reactivation of exhausted virus-specific CD8+ T cells and efficiently reduces chronic retroviral loads. Dietze KK et al., 2013, PLoS Pathog

Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor. McGray AJ et al., 2014 Jan, Mol Ther

Virus-specific CD8+ T cells upregulate programmed death-1 expression during acute friend retrovirus infection but are highly cytotoxic and control virus replication. Zelinskyy G et al., 2011 Oct 1, J Immunol