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Product image
InVivoMAb anti-mouse/human CD11b
BE0007
ApplicationsFlow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierBio X Cell
- Product NameInVivoMAb anti-mouse/human CD11b
- Delivery Days Customer7
- ApplicationsFlow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDM1/70
- Concentration4-11 mg/ml
- HostRat
- IsotypeIgG2b
- Scientific DescriptionThe M1/70 monoclonal antibody reacts with mouse and human CD11b, a 170 kDa membrane glycoprotein also known as integrin alpha M (ITGAM). CD11b belongs to the integrin alpha family and is primarily expressed on granulocytes and monocytes/macrophages but also expressed on dendritic cells, NK cells, and subsets of T and B cells. CD11b and CD18 combine to form Mac-1. Mac-1 functions as a complement receptor as well as a receptor for fibrinogen, factor X, and ICAM1.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Collaborative interactions between type 2 innate lymphoid cells and antigen-specific CD4+ Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia. Liu B et al., 2015 Apr 15, J ImmunolRead more
- ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Becker AM et al., 2015 Jan, Exp HematolRead more
- Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. Yokota N et al., 2014 Jan, J Thromb HaemostRead more
- Intravital 2-photon imaging of leukocyte trafficking in beating heart. Li W et al., 2012 Jul, J Clin InvestRead more
- Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Ahn GO et al., 2010 May 4, Proc Natl Acad Sci U S ARead more
