InVivoMAb anti-mouse/human CD11b

Name: InVivoMAb anti-mouse/human CD11b
SKU: BE0007_B56
Availability: BackOrder

BE0007

ApplicationsFlow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation

Product group Antibodies

ReactivityHuman, Mouse

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse/human CD11b
Delivery Days Customer
7
Applications
Flow Cytometry, Neutralisation/Blocking, Purification/Extraction/Isolation
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
M1/70
Concentration
4-11 mg/ml
Estimated Purity
>95%
Host
Rat
Isotype
IgG2b
Scientific Description
The M1/70 monoclonal antibody reacts with mouse and human CD11b, a 170 kDa membrane glycoprotein also known as integrin alpha M (ITGAM). CD11b belongs to the integrin alpha family and is primarily expressed on granulocytes and monocytes/macrophages but also expressed on dendritic cells, NK cells, and subsets of T and B cells. CD11b and CD18 combine to form Mac-1. Mac-1 functions as a complement receptor as well as a receptor for fibrinogen, factor X, and ICAM1.
Reactivity
Human, Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Collaborative interactions between type 2 innate lymphoid cells and antigen-specific CD4+ Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia. Liu B et al., 2015 Apr 15, J Immunol
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ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Becker AM et al., 2015 Jan, Exp Hematol
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Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice. Yokota N et al., 2014 Jan, J Thromb Haemost
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Intravital 2-photon imaging of leukocyte trafficking in beating heart. Li W et al., 2012 Jul, J Clin Invest
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Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment. Ahn GO et al., 2010 May 4, Proc Natl Acad Sci U S A
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