InVivoPlus anti-mouse/human/rat CD47 (IAP)

Bio X Cell

InVivoPlus anti-mouse/human/rat CD47 (IAP)

7

ImmunoFluorescence, Neutralisation/Blocking

Research Use Only

Monoclonal

MIAP410

4-11 mg/ml

>95%

Mouse

IgG1

The MIAP410 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells. Because of this, anti-CD47 monoclonal antibodies have been proposed and studied as a therapeutic treatment for human cancers. The MIAP410 antibody has been shown to neutralize CD47 in vivo and in vitro.

Human, Mouse, Rat

2°C to 8°C

12352203