InVivoPlus anti-mouse/human/rat CD47 (IAP)

Name: InVivoPlus anti-mouse/human/rat CD47 (IAP)
SKU: BP0283_B56
Price: 6416 EUR
Availability: BackOrder

BP0283

ApplicationsImmunoFluorescence, Neutralisation/Blocking

Product group Antibodies

ReactivityHuman, Mouse, Rat

Overview

Supplier
Bio X Cell
Product Name
InVivoPlus anti-mouse/human/rat CD47 (IAP)
Delivery Days Customer
7
Applications
ImmunoFluorescence, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
MIAP410
Concentration
4-11 mg/ml
Host
Mouse
Isotype
IgG1
Scientific Description
The MIAP410 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells. Because of this, anti-CD47 monoclonal antibodies have been proposed and studied as a therapeutic treatment for human cancers. The MIAP410 antibody has been shown to neutralize CD47 in vivo and in vitro.
Reactivity
Human, Mouse, Rat
Storage Instruction
2°C to 8°C
UNSPSC
12352203

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Kojima Y et al., 2016 Aug 4, Nature
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The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Willingham SB et al., 2012 Apr 24, Proc Natl Acad Sci U S A
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CD47, a ligand for the macrophage fusion receptor, participates in macrophage multinucleation. Han X et al., 2000 Dec 1, J Biol Chem
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