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INVS Antibody, Biotin conjugated

CSB-PA011769LD01HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetINVS
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Overview

  • Supplier
    Cusabio
  • Product Name
    INVS Antibody, Biotin conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Biotin
  • Gene ID27130
  • Target name
    INVS
  • Target description
    inversin
  • Target synonyms
    INV, NPH2, NPHP2, inversin, inversion of embryo turning homolog, inversion of embryonic turning, nephrocystin-2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y283
  • Protein Name
    Inversin
  • Scientific Description
    Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

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