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ProductsBack/INVS Antibody, FITC conjugated

INVS Antibody, FITC conjugated

CSB-PA011769LC01HU

ReactivityHuman

Product group Antibodies

TargetINVS

Overview

Supplier
Cusabio
Product Name
INVS Antibody, FITC conjugated
Delivery Days Customer
20
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
FITC
Gene ID27130
Target name
INVS
Target description
inversin
Target synonyms
INV, NPH2, NPHP2, inversin, inversion of embryo turning homolog, inversion of embryonic turning, nephrocystin-2
Host
Rabbit
Isotype
IgG
Protein IDQ9Y283
Protein Name
Inversin
Scientific Description
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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