Isorhamnetin [480-19-3]

TargetMol Chemicals

Isorhamnetin [480-19-3]

4

480-19-3

Chemical

Research Use Only

Isorhamnetin

0.9282

C16H12O7

316.26

Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LDL via inhibition of lectin-like ox-LDL receptor-1 upregulation, interference of ox-LDL-mediated intracellular signaling pathway (p38MAPK activation, NF-kappaB nuclear translocation, eNOS expression) and the antioxidant activity of isorhamnetin. Isorhamnetin prevents endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II. Isorhamnetin appears to be a potent drug against esophageal cancer due to its in vitro potential to not only inhibit proliferation but also induce apoptosis of Eca-109 cells.

3 years

COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O

-20°C

12352200