ITCH (N1) Antibody, Rabbit Polyclonal

Biorbyt

ITCH (N1) Antibody, Rabbit Polyclonal

16

Western Blot

WB:1:500-1:1000 WB

Research Use Only

Polyclonal

Unconjugated

ITCH

itchy E3 ubiquitin protein ligase

ADMFD, AIF4, AIP4, NAPP1, E3 ubiquitin-protein ligase Itchy homolog, HECT-type E3 ubiquitin transferase Itchy homolog, NFE2-associated polypeptide 1, atrophin-1 interacting protein 4, itchy E3 ubiquitin protein ligase homolog

Rabbit

E3 ubiquitin-protein ligase Itchy homolog

Rabbit polyclonal to ITCH.E3 ubiquitin-protein ligase Itchy homolog (ITCH) acts as an E3 ubiquitin-protein ligase. ITCHubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It isinvolved in the negative regulation of MAVS-dependent cellular antiviral responses. ITCH is involvedin the regulation of apoptosis and reactive oxygen species levels through the ubiquitination andproteasomal degradation of TXNIP. It mediates the antiapoptotic activity of epidermal growth factorthrough the ubiquitination and proteasomal degradation of p15 BID. Defects in ITCH are the cause ofsyndromic multisystem autoimmune disease (SMAD).

Human

-20°C

12352203