Ivosidenib [1448347-49-6]

MedChem Express

Ivosidenib [1448347-49-6]

10

1448347-49-6

Research Use Only

99.85

C28H22ClF3N6O3

582.96

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1].

ClC1=C([C@H](N(C2=CC(F)=CN=C2)C([C@H]3N(C4=NC=CC(C#N)=C4)C(CC3)=O)=O)C(NC5CC(F)(F)C5)=O)C=CC=C1

-20°C,2°C to 8°C

12352200