IWR-1

MedChem Express

IWR-1 [1127442-82-3]

5

1127442-82-3

Research Use Only

99.60

C25H19N3O3

409.44

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/beta-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of beta-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/beta-catenin downstream targets. IWR-1 induces increase in Axin protein levels accompanied by elevated levels of beta-catenin. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis[1][2][4].

O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([C@]4([H])[C@](C5)([H])C=C[C@]5([H])[C@]64[H])=O)C6=O)C=C3

-20°C,2°C to 8°C

12352200