J-113863

MedChem Express

J-113863 [353791-85-2]

9

353791-85-2

Research Use Only

99.0

C30H37Cl2IN2O2

655.44

J-113863 is a potent and selective CCR1 antagonist with IC 50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 ( IC 50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 ( IC 50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-alpha receptors. Anti-inflammatory effect [1] [2] [3] .

CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]

2°C to 8°C

12352200