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J-113863 [353791-85-2]

J-113863 [353791-85-2]

T11699
TargetMol Chemicals
CAS Number353791-85-2
Product group Chemicals
Molecular Weight655.44
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    J-113863 [353791-85-2]
  • Delivery Days Customer
    4
  • CAS Number
    353791-85-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    J-113863
  • Molecular Formula
    C30H37Cl2IN2O2
  • Molecular Weight
    655.44
  • Scientific Description
    J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-alpha receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.
  • Shelf life instruction
    3 years
  • SMILES
    [I-].CC[N+]1(C\C2=C\CCCCCC2)CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc12
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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