JAK3 covalent inhibitor-1 [2300106-50-5]

MedChem Express

JAK3 covalent inhibitor-1 [2300106-50-5]

10

2300106-50-5

Research Use Only

C22H17FN6O2S

448.47

JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1].

O=S(N[C@H](C[C@@H]1NC#N)C(C1=C2)=CC=C2C3=C4C(NC=C4)=NC=N3)(C5=CC=CC(F)=C5)=O

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