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JH-X-119-01

ORB1089899
Biorbyt
CAS Number2227368-54-7
Product group Chemicals
Molecular Weight452.474
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Overview

  • Supplier
    Biorbyt
  • Product Name
    JH-X-119-01 [2227368-54-7]
  • Delivery Days Customer
    10
  • CAS Number
    2227368-54-7
  • Certification
    Research Use Only
  • Molecular Formula
    C25H20N6O3
  • Molecular Weight
    452.474
  • Scientific Description
    Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.
  • SMILES
    O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3
  • UNSPSC
    12352200

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