JKE-1674

AbMole BioScience

JKE-1674

9

2421119-60-8

Chemical

Research Use Only

C20H20Cl2N4O4

451.30

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1.

ON=C(C[N](=O)=O)C(=O)N1CCN(CC1)C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3

2-8°C, protect from light, sealed

12352200