JNJ-5207787

MedChem Express

JNJ-5207787 [683746-68-1]

10

683746-68-1

Research Use Only

98.00

C32H38N4O2

510.67

JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y 2 receptor (Y 2 ) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC 50 s of 7.0 and 7.1 for human Y 2 receptor and rat Y 2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y 1 , Y 4 , and Y 5 receptors [1] .

N#CC1=CC=CC(/C=C/C(N(C2CCN(CCC3CCCC3)CC2)C4=CC=C(CCN5C(C)=O)C5=C4)=O)=C1

-20°C

12352200