JNJ-5207787

Biorbyt

JNJ-5207787 [683746-68-1]

10

683746-68-1

Research Use Only

98.00%

C32H38N4O2

510.67

JNJ-5207787 is a penetrates the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. It is > 100-fold selective versus human Y1, Y4, and Y5 receptors. JNJ-5207787 suppresses the binding of peptide YY with pIC50s of 7.0 and 7.1 for the human Y2 receptor and rat Y2 receptor, respectively.

N(C(/C=C/C1=CC(C#N)=CC=C1)=O)(C=2C=C3C(=CC2)CCN3C(C)=O)C4CCN(CCC5CCCC5)CC4

-20°C

12352200