JNJ-63576253 (free base) [2110426-27-0]

MedChem Express

JNJ-63576253 (free base) [2110426-27-0]

10

2110426-27-0

Research Use Only

C23H21F3N6O2S

502.51

JNJ-63576253 (TRC-253) free base is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 free base can be used for the research of castration-resistant prostate cancer (CRPC)[1].

O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5

12352200