JNJ-63576253

AbMole BioScience

JNJ-63576253

9

2110428-64-1

Chemical

Research Use Only

C23H22ClF3N6O2S

538.97

JNJ-63576253 (TRC-253) is a potent and orally active complete antagonist of the androgen receptor against F877L mutant AR and wild-type AR in LNCaP cells IC50 The values are 37 and 54 nM, respectively. JNJ-63576253 can be used in the study of castration-resistant prostate cancer (CRPC).

Cl.FC(F)(F)C1=CC(=CN=C1C#N)N2C(=O)C3(CCC3)N(C2=S)C4=CN=C(OC5CCNCC5)C=C4

12352200