JNK (phospho Thr183/Tyr185) antibody

GeneTex

JNK (phospho Thr183/Tyr185) antibody

9

This antibody is raised against JNK1/2 phosphorylated at Thr183/Tyr185. Based on sequence homology, it is predicted to react with JNK3 when phosphorylated at the corresponding residues - Thr221/Tyr223.

Western Blot

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

MAPK8

mitogen-activated protein kinase 8

c-Jun N-terminal kinase 1; JNK; JNK1; JNK1A2; JNK21B1/2; JNK-46; JUN N-terminal kinase; MAP kinase 8; mitogen-activated protein kinase 8; PRKM8; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c

Rabbit

IgG

Phosphorylated

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Human, Mouse, Rat

2°C to 8°C,-20°C or -80°C

12352203