JNK (phospho Tyr185) antibody

GeneTex

JNK (phospho Tyr185) antibody

9

WB 1:500-1:2000, IHC 1:50-1:200

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MAPK8

mitogen-activated protein kinase 8

JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c, mitogen-activated protein kinase 8, JUN N-terminal kinase, MAP kinase 8, c-Jun N-terminal kinase 1, stress-activated protein kinase 1, stress-activated protein kinase 1c

Rabbit

IgG

Mitogen-activated protein kinase 8

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203