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Western blot analysis of SAPK/JNK phosphorylation expression in nocodazole treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of SAPK/JNK phosphorylation expression in nocodazole treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Western blot analysis of SAPK/JNK phosphorylation expression in nocodazole treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

JNK (phospho Tyr185) antibody

Research Use Only
GTX52328
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMAPK8
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    JNK (phospho Tyr185) antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is raised against JNK1/2 phosphorylated at Tyr185. Based on sequence homology, it is predicted to react with JNK3 when phosphorylated at the corresponding residues - Tyr223.
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5599
  • Target name
    MAPK8
  • Target description
    mitogen-activated protein kinase 8
  • Target synonyms
    c-Jun N-terminal kinase 1; JNK; JNK1; JNK1A2; JNK21B1/2; JNK-46; JUN N-terminal kinase; MAP kinase 8; mitogen-activated protein kinase 8; PRKM8; SAPK1; SAPK1c; stress-activated protein kinase 1; stress-activated protein kinase 1c
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Micronized sacchachitin promotes satellite cell proliferation through TAK1-JNK-AP-1 signaling pathway predominantly by TLR2 activation. Wu MH et al., 2020 Sep 22, Chin Med
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  • Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice. Hsieh YH et al., 2018 Sep 1, Nutrients
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  • The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Chen PH et al., 2016 Nov, Neuropharmacology
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