JNK2 Polyclonal Antibody

Reddot Biotech

JNK2 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.4 mg/ml

Unconjugated

MAPK9

mitogen-activated protein kinase 9

c-Jun kinase 2; c-Jun N-terminal kinase 2; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-55; Jun kinase; MAP kinase 9; MAPK 9; mitogen-activated protein kinase 9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a; stress-activated protein kinase 1a; stress-activated protein kinase JNK2

Rabbit

IgG

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Human, Mouse, Rat

-20°C

12352203