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(-)-JQ1 [1268524-71-5]

(-)-JQ1 [1268524-71-5]

27334
BPS Bioscience
CAS Number1268524-71-5
Product group Chemicals
Molecular Weight457.0 kDa
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    (-)-JQ1 [1268524-71-5]
  • Delivery Days Customer
    7
  • CAS Number
    1268524-71-5
  • Certification
    Research Use Only
  • Molecular Formula
    C23H25ClN4O2S
  • Molecular Weight
    457.0 kDa
  • Scientific Description
    (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.
  • UNSPSC
    12161509

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