K-252a

MedChem Express

K-252a [99533-80-9]

10

99533-80-9

Research Use Only

99.45

C27H21N3O5

467.47

K-252a, a staurosporine analog, inhibits protein kinase , with IC 50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca 2+ /calmodulin-dependent kinase type II, and phosphorylase kinase, respectively [1] [2] . K-252a is a potent inhibitor (IC 50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene [3] .

O=C(NC1)C2=C1C3=C4C5=C2C6=C(C=CC=C6)N5[C@](C[C@]7(O)C(OC)=O)([H])O[C@]7(C)N4C8=C3C=CC=C8

-20°C

12352200