KDM5A-IN-1

MedChem Express

KDM5A-IN-1 [1905481-36-8]

10

1905481-36-8

Research Use Only

99.95

C15H22N4O2

290.367

KDM5A-IN-1 is a potent, orally bioavailable pan- histone lysine demethylases 5 (KDM5) inhibitor with IC 50 s of 45 nM, 56 nM and 55 nM for KDM5A , KDM5B and KDM5C , respectively, and with an EC 50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B) [1] .

O=C(C1CC1)N[C@@H]2CCN(C(C3=CC(C(C)C)=NN3)=O)C2

-20°C,2°C to 8°C

12352200