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Kira8 [1630086-20-2]

Kira8 [1630086-20-2]

T11762L
TargetMol Chemicals
CAS Number1630086-20-2
Product group Chemicals
Estimated Purity98.07%
Molecular Weight601.12
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Kira8 [1630086-20-2]
  • Delivery Days Customer
    9
  • CAS Number
    1630086-20-2
  • Certification
    Research Use Only
  • Chemical Name
    Kira8
  • Estimated Purity
    98.07%
  • Molecular Formula
    C31H29ClN6O3S
  • Molecular Weight
    601.12
  • Scientific Description
    Kira8 (AMG-18) is a mono-selective IRE1alpha inhibitor that allosterically attenuates IRE1alpha RNase activity with an IC50 of 5.9 nM.
  • Shelf life instruction
    3 years
  • SMILES
    Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Morita S, Villalta SA, Feldman HC, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017,25(4):883-897.e8. doi: 10.1016/j.cmet.2017.03.018
    Read this paper

MSDS

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