KPNA2 antibody [2G7]

GeneTex

KPNA2 antibody [2G7]

9

Recommended Starting Dilutions:For WB: Use at 1:1000Optimal dilutions should be determined experimentally by the researcher.

Western Blot

Research Use Only

Monoclonal

2G7

1 mg/ml

Unconjugated

KPNA2

karyopherin subunit alpha 2

IPOA1, PTAC58, QIP2, RCH1, SRP1-alpha, SRP1alpha, importin subunit alpha-1, RAG cohort protein 1, importin subunit alpha-2, importin-alpha-P1, karyopherin alpha 2 (RAG cohort 1, importin alpha 1), nuclear pore-targeting complex 58kD component, pendulin

Rat

IgG2a

Importin subunit alpha-1

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

-20°C or -80°C,2°C to 8°C

12352203