KRAS inhibitor-9

Biorbyt

KRAS inhibitor-9 [300809-71-6]

10

300809-71-6

Research Use Only

C13H9CLN2S2

292.8069589

KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 microM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.

ClC1C([H])=C(C([H])=C([H])C=1SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1)N([H])[H]

12352200