KRT17 Antibody

Cusabio

KRT17 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

KRT17

keratin 17

39.1, CK-17, K17, PC, PC2, PCHC1, keratin, type I cytoskeletal 17, cytokeratin-17, keratin 17, type I

Rabbit

IgG

Keratin, type I cytoskeletal 17

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity. M Rosenberg, Mol. Cell. Biol., Feb 1988; 8: 722 - 736. SM Troyanovsky, J. Cell Sci., Jul 1989; 93: 419. Kevin M. McGowan, Genes & Dev., Jun 2002; 16: 1412. Nicholas Bianchi, Mol. Cell. Biol., Aug 2005; 25: 7249 - 7259.

Human, Mouse, Rat

-20°C or -80°C

41116161