Ku70 antibody [529]
GTX77607
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
TargetXRCC6
Overview
- SupplierGeneTex
- Product NameKu70 antibody [529]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:5000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID529
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID2547
- Target nameXRCC6
- Target descriptionX-ray repair cross complementing 6
- Target synonymsCTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross-complementing protein 6, 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding factor 75 kDa subunit, DNA repair protein XRCC6, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, X-ray repair complementing defective repair in Chinese hamster cells 6, lupus Ku autoantigen protein p70, thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70
- HostMouse
- IsotypeIgG1
- Protein IDP12956
- Protein NameX-ray repair cross-complementing protein 6
- Scientific DescriptionThe p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Mladenov E, Fan X, Paul-Konietzko K, et al. DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells. Sci Rep. 2019,9(1):14597. doi: 10.1038/s41598-019-51071-6Read this paper
- Mladenov E, Fan X, Dueva R, et al. Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase. Sci Rep. 2019,9(1):8255. doi: 10.1038/s41598-019-44771-6Read this paper
- Wang CY, Huang EY, Huang SC, et al. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. Oncogene. 2015,34(10):1263-9. doi: 10.1038/onc.2014.74Read this paper



![ICC/IF analysis of methanol-fixed HeLa cells using GTX66844 Ku70 antibody [7B1]. Dilution : 1:200](https://www.genetex.com/upload/website/prouct_img/normal/GTX66844/GTX66844_20190305_ICCIF_w_23061221_857.webp)