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Ku70 antibody

GTX101820
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
TargetXRCC6
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ku70 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.25 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2547
  • Target name
    XRCC6
  • Target description
    X-ray repair cross complementing 6
  • Target synonyms
    CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross-complementing protein 6, 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding factor 75 kDa subunit, DNA repair protein XRCC6, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, X-ray repair complementing defective repair in Chinese hamster cells 6, lupus Ku autoantigen protein p70, thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP12956
  • Protein Name
    X-ray repair cross-complementing protein 6
  • Scientific Description
    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • Chakraborty A, Tapryal N, Islam A, et al. Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks. J Biol Chem. 2023,299(3):102991. doi: 10.1016/j.jbc.2023.102991
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  • Rowley PA, Ellahi A, Han K, et al. Nuku, a family of primate retrocopies derived from KU70. G3 (Bethesda). 2021,11(8). doi: 10.1093/g3journal/jkab163
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  • Chen TY, Huang BM, Tang TK, et al. Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response. Cell Death Differ. 2021,28(6):1865-1879. doi: 10.1038/s41418-020-00713-8
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  • Chen TY, Lin TC, Kuo PL, et al. Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150(glued). J Cell Physiol. 2021,236(4):2706-2724. doi: 10.1002/jcp.30037
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  • Wang CY, Tsai SW, Chien HH, et al. Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis. Drug Des Devel Ther. 2020,14:2987-3000. doi: 10.2147/DDDT.S252401
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  • Bottoni G, Katarkar A, Tassone B, et al. CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Nat Commun. 2019,10(1):3884. doi: 10.1038/s41467-019-11785-7
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  • Chen MK, Du Y, Sun L, et al. H(2)O(2) induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. J Biol Chem. 2019,294(21):8516-8528. doi: 10.1074/jbc.RA118.005953
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