Bio-Connect

Ku70 antibody

GTX101820
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse
TargetXRCC6
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ku70 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.25 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID2547
  • Target name
    XRCC6
  • Target description
    X-ray repair cross complementing 6
  • Target synonyms
    5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; KU70; lupus Ku autoantigen protein p70; ML8; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP12956
  • Protein Name
    X-ray repair cross-complementing protein 6
  • Scientific Description
    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease.
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  • Nuclear proinflammatory cytokine S100A9 enhances expression of human papillomavirus oncogenes via transcription factor TEAD1.
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  • Human DNA polymerase eta promotes RNA-templated error-free repair of DNA double-strand breaks.
    Read more
  • Nuku, a family of primate retrocopies derived from KU70. Rowley PA et al., 2021 Aug 7, G3 (Bethesda)
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  • Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response. Chen TY et al., 2021 Jun, Cell Death Differ
    Read more
  • Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis. Ma M et al., 2021 Feb 1, J Exp Med
    Read more
  • Septin 7 is a centrosomal protein that ensures S phase entry and microtubule nucleation by maintaining the abundance of p150glued. Chen TY et al., 2021 Apr, J Cell Physiol
    Read more
  • Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis. Wang CY et al., 2020, Drug Des Devel Ther
    Read more
  • CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Bottoni G et al., 2019 Aug 29, Nat Commun
    Read more
  • H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. Chen MK et al., 2019 May 24, J Biol Chem
    Read more