Ku80 antibody

Name: Ku80 antibody
SKU: GTX70485_G10
Availability: BackOrder

GTX70485

ApplicationsWestern Blot, ELISA

Product group Antibodies

ReactivityHuman, Mouse

Overview

Supplier
GeneTex
Product Name
Ku80 antibody
Delivery Days Customer
9
Application Supplier Note
Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
Applications
Western Blot, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Host
Rabbit
Isotype
IgG
Scientific Description
Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

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Read this paper
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Wright TM, Rathmell WK. Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma. J Biol Chem. 2010,285(17):12916-24. doi: 10.1074/jbc.M109.073924
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Myers K, Gagou ME, Zuazua-Villar P, et al. ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet. 2009,5(1):e1000324. doi: 10.1371/journal.pgen.1000324
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Hacker KE, Lee CM, Rathmell WK. VHL type 2B mutations retain VBC complex form and function. PLoS One. 2008,3(11):e3801. doi: 10.1371/journal.pone.0003801
Read this paper