Ku80 antibody
GTX70485
Overview
- SupplierGeneTex
- Product NameKu80 antibody
- Delivery Days Customer9
- Antibody SpecificityReacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse rat and hamster.
- Application Supplier NoteWestern blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- HostRabbit
- IsotypeIgG
- Scientific DescriptionTelomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy. Lipner MB et al., 2020 Apr 23, JCI InsightRead more
- XRN2 Links Transcription Termination to DNA Damage and Replication Stress. Morales JC et al., 2016 Jul, PLoS GenetRead more
- mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma. Bailey ST et al., 2014, PLoS OneRead more
- Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma. Wright TM et al., 2010 Apr 23, J Biol ChemRead more
- ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. Myers K et al., 2009 Jan, PLoS GenetRead more
- VHL type 2B mutations retain VBC complex form and function. Hacker KE et al., 2008, PLoS OneRead more