Bio-Connect

Ku80 antibody

Research Use Only
GTX70486
GeneTex
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ku80 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Reacts with residues 419-440 [LVYVQLPFMEDLRQYMFSSLKN] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse, rat and hamster.
  • Application Supplier Note
    Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203