Bio-Connect

Ku80 antibody [N3C2], Internal

GTX109935
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
TargetXRCC5
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Ku80 antibody [N3C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.41 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7520
  • Target name
    XRCC5
  • Target description
    X-ray repair cross complementing 5
  • Target synonyms
    KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, X-ray repair cross-complementing protein 5, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku autoantigen, 80kDa, Ku86 autoantigen related protein 1, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining), lupus Ku autoantigen protein p86, nuclear factor IV, thyroid-lupus autoantigen
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP13010
  • Protein Name
    X-ray repair cross-complementing protein 5
  • Scientific Description
    The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chen RY, Lin CJ, Liang ST, et al. UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Animals (Basel). 2020,10(6). doi: 10.3390/ani10061096
    Read this paper
  • Bottoni G, Katarkar A, Tassone B, et al. CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Nat Commun. 2019,10(1):3884. doi: 10.1038/s41467-019-11785-7
    Read this paper
  • Chen MK, Du Y, Sun L, et al. H(2)O(2) induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. J Biol Chem. 2019,294(21):8516-8528. doi: 10.1074/jbc.RA118.005953
    Read this paper
  • Chang CF, Chu PC, Wu PY, et al. PHRF1 promotes genome integrity by modulating non-homologous end-joining. Cell Death Dis. 2015,6(4):e1716. doi: 10.1038/cddis.2015.81
    Read this paper
  • You BJ, Wu YC, Lee CL, et al. Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells. Food Chem Toxicol. 2014,65:205-12. doi: 10.1016/j.fct.2013.12.026
    Read this paper
  • Chiang JH, Yang JS, Lu CC, et al. Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: evidence for γH2A.X and DNA-PK-dependent pathway. Hum Exp Toxicol. 2014,33(6):590-601. doi: 10.1177/0960327113504791
    Read this paper
  • Masuda Y, Noguchi K, Segawa H, et al. Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. Biochem Biophys Res Commun. 2011,415(2):305-12. doi: 10.1016/j.bbrc.2011.10.050
    Read this paper