Ku80 antibody [N3C2], Internal
GTX109935
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetXRCC5
Overview
- SupplierGeneTex
- Product NameKu80 antibody [N3C2], Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.41 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID7520
- Target nameXRCC5
- Target descriptionX-ray repair cross complementing 5
- Target synonyms86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; KARP1; KARP-1; Ku autoantigen, 80kDa; KU80; Ku86; Ku86 autoantigen related protein 1; KUB2; lupus Ku autoantigen protein p86; NFIV; nuclear factor IV; thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5
- HostRabbit
- IsotypeIgG
- Protein IDP13010
- Protein NameX-ray repair cross-complementing protein 5
- Scientific DescriptionThe protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY et al., 2020 Jun 25, Animals (Basel)Read more
- CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Bottoni G et al., 2019 Aug 29, Nat CommunRead more
- H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. Chen MK et al., 2019 May 24, J Biol ChemRead more
- PHRF1 promotes genome integrity by modulating non-homologous end-joining. Chang CF et al., 2015 Apr 9, Cell Death DisRead more
- Non-homologous end joining pathway is the major route of protection against 4beta-hydroxywithanolide E-induced DNA damage in MCF-7 cells. You BJ et al., 2014 Mar, Food Chem ToxicolRead more
- Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells: evidence for gammaH2A.X and DNA-PK-dependent pathway. Chiang JH et al., 2014 Jun, Hum Exp ToxicolRead more
- Novel regulatory role for Kaposis sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin. Masuda Y et al., 2011 Nov 18, Biochem Biophys Res CommunRead more