Lactacystin [133343-34-7]

AdipoGen Life Sciences

Lactacystin

10

133343-34-7

Research Use Only

>98%

C15H24N2O7S

376.4

Chemical. CAS: 133343-34-7. Formula: C15H24N2O7S. MW: 376.4. Isolated from Streptomyces lactacystinnaeus strain OM-6519. Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-kappaB activation by inhibiting IkappaB degradation. Cathepsin A inhibitor. beta-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer. - Induces neuritogenesis [1, 3]. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex) [2, 4, 7]. Blocks proteasome activity by targeting the catalytic beta-subunit [5]. Apoptosis inducer [4, 6, 7, 10]. Anticancer compound [6, 10, 13]. Upregulates HSP70 and HSP22 [8]. Induces differentiation and inhibits cell cycle progression in several tumor cell lines [9]. Inhibits NF-kappaB activation by inhibiting IkappaB degradation [11]. Cathepsin A inhibitor [12]. beta-Secretase activity inhibitor [14]. Anti-adipogenic [15, 16]. Autophagy inducer [17].

CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O

-20°C,2°C to 8°C

12352200