Laduviglusib (CHIR-99021) HCl

Selleck Chemicals

Laduviglusib (CHIR-99021) HCl [1797989-42-4]

9

Research Use Only

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Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3alpha/beta inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORalpha and autophagy-related proteins.

-80°C

51202000